Anti-Aging starts from the moment of birth!
At what age should humans consider Anti-Aging Medicine?
In current society, it is possible for an 80-year-old person to climb the world’s highest mountain, Everest, and entrepreneurs are nurtured from elementary school due to new forms of education. Today, the classification of social structure by age using terms such as “child”, “adult” and “elderly” has gradually become ambiguous.
In other words, we are entering an era of the “Uni-age”.
Therefore, the Anti-Aging Medical Society does not take into consideration a person’s age. Indeed, Anti-Aging Medicine should be considered from the moment of birth!
Purpose and interests of Anti-Aging Medicine
When someone asks you about “aging”, what image comes to your mind?
Cognitive decline, muscle weakness, osteoporosis, increased visceral fat, decreased cardiovascular function, and insomnia are general aging phenotypes. These manifest medical symptoms such as oxidative stress, immune response, persistent inflammation, and circadian cycle and autonomic nervous system disorders. The fundamental cause of these diseases is due to reactive oxygen species-induced genetic damage and instability. The ability to eliminate reactive oxygen species when young declines with age.
In recent years, we have learned that many diseases are linked to increase in oxidative stress, and the subject of “how to reduce the generation of reactive oxygen species” is one of the major objectives of Anti-Aging Medicine. Because reactive oxygen species are produced by mitochondria during energy conversion after eating, limiting caloric intake to begin with is one countermeasure.
It has been demonstrated in various animal studies that caloric restriction can lead to extended lifespan. It was discovered that caloric restriction had the effect of turning on the longevity gene “sirtuin” at a molecular level.
A chromosome which is coiled like a in a helix becomes unraveled during gene transcription. During this state DNA becomes vulnerable to reactive oxygen species damage, and sirtuin works to tighten back the loosened coils. To put it briefly, it plays a big role in “protection against genetic damage”. Therefore, “how to increase sirtuins” is a subject of great interest in Anti-Aging Medicine. Aerobic exercise, resistance exercise, increasing the sex hormone testosterone, ingestion of COQ 10 and polyphenol, administration of drugs such as PDE 5 inhibitor, are established methods for increasing sirtuin production.
Reason for choosing the word “Anti-Aging”
The word “anti” in Anti-Aging Medicine means “action against the negative”.
Recently, there are opinions that prefer the use of words such as successful-aging and well-aging. Certainly, these words may be appropriate in the context of social adaptation of the elderly.
However, we must not forget that Anti-Aging Medicine is an academic field that promotes the prevention of “negative” phenomena caused by aging. Considering that aging has a constant negative effect on genes, I think that it would be appropriate for medical professionals to choose the word “Anti-Aging”.
Progress and future of Anti-Aging Medicine
You are all aware of the rapid progress of Anti-Aging Medicine in the past five years. There has been great progress from laboratory research into clinical studies. As an example, in an experiment were gastric arteries of old and young mice were connected, blood vessel development, neural stem cell proliferation, heightened sense of smell and skeletal muscle regeneration was observed in old mice. We have also learned about the causative molecule Growth Differentiation Factor-11 (GDF-11). Many companies are now focusing on how to activate GDF-11.
The era of disease prevention by Anti-Aging Medicine
Have you heard of the word “SmartCare”?
It is a medical system that was developed in the United States where doctors and other medical professionals, such as nurses and nutritionists, collaborate to prevent cancer and help patients with cancer by using independent data. What is surprising is that they can change gene expression through functional foods, exercise, and stress management. Through this, it is possible to delay the progression of cancer or prevent cancer. In other words, we live in an era where we can prevent disease through an Anti-Aging program. This has also drawn attention as an effective means to reduce medical expenses.
Our slogan is “Liveliness”!
While modern medicine is segmented into different areas, it has fallen into a silo effect that is poorly integrated. However, in order to integrate scientific research into society, it is important to share the knowledge in a cross-functional manner within the silo, and I believe that this is the mission of Japanease Society of Anti-aging Mecicine.
The field covered by Anti-Aging Medicine is very wide.
The objective of Anti-Aging Medicine is to improve genetic phenotype, as well as solve physical and mental problems that are factors preventing elderly people from participating in society. This will also promote the effect of “anti-nursing care”.
Also, social capital in organizations and communities is also an important element of Anti-Aging Medicine. Therefore, in addition to the self-assessment for “well-being” advocated by former president Prof. Tsubota, I would like to advocate a peer-assessment for “liveliness”.
Society’s happiness begins by supporting Anti-Aging.
I believe that Anti-Aging Medicine can support the realization of an open society which is “lively”.
Japanese Society of Anti-Aging Medicine
President Shigeo Horie, MD, Ph D.
Professor and Chairman, Department of UrologyJuntendo University,
Graduate School of Medicine Chief, Urology Service Juntendo Hospital
1.About Japanese Society of Anti-Aging Medicine(JAAM)
The Japanese Society of Anti-Aging Medicine (JAAM) initially founded as the Academy of Anti-Aging Medicine Japan with 20 doctors in 2001. It was then reorganized as JAAM in April 2003, and incorporated as a limited liability intermediate corporation in July 2006.
With a membership of more than 8,200 individuals covering a wide and diverse range of basic research and clinical specialties, JAAM has grown into one of the largest academic societies dedicated to the advancement of Anti-Aging Medicine in Japan.
Anti-Aging Medicine deals with the biological process of aging. It aims to prevent diseases, including lifestyle-related diseases; to control factors that promote the occurrence of disease, including stress, fatigue, and immunological deterioration; and to promote and prolong a healthy life span. Insights yielded in this field are also helpful in scientifically elucidating phenomena occurring in biological processes throughout life, from birth to death.
From the genetic and cellular level to the individual level of animals and humans, Anti-Aging Medicine covers diverse fields of medical science, including biochemistry, physiology, and clinical medicine, and takes a multidisciplinary approach involving chemistry, physics, agriculture, pharmacy and others.
Research results are utilized in the practice of Anti-Aging Medicine, which is supported by replacement herapy based on nutrition and endocrinology, and lifestyle improvement, including physical exercise and rest.
The clinical practice of Anti-Aging Medicine can be approved only when it is validated on the basis of scientific evidence. In this context JAAM pursues the practice of Anti-Aging Medicine that is scientifically evidence-based.
The mission of JAAM is three-fold: to advance Anti-Aging Medicine, a basic element of healthcare in the 21st century, to accumulate and analyze aging- and anti-aging-related data, and to appropriately approve practice on the basis of scientific evidence, thereby promoting the practice of Anti-Aging Medicine.
Through the advancement of Anti-Aging Medicine, JAAM helps contribute to improving the well-being of people everywhere.
In 2001, the year when the Academy of Anti-Aging Medicine Japan was established, the coming of the aging society was already foreseen, with fewer children and marked increases in medical costs for the elderly. The universal healthcare system of Japan was expected to come under pressure, with many anticipating a change in policy and direction. In theses circumstances and amid the advance in research into aging and related phenomena, the Academy of Anti-Aging Medicine Japan was founded by physicians and researchers to make active use of Anti-Aging Medicine, in both basic and clinical medicine, and encourage prevention of the pathological processes of aging, thereby improving quality of life.
Anti-Aging Medicine contributes to promoting and prolonging a healthy life span, reducing increases in medical expenses for the elderly, extending productive age, and securing an adequate workforce, all of which should be part of a national strategy.
Reorganized as the Japanese Society of Anti-Aging Medicine (JAAM) in April 2003,
we continue to dedicate our best efforts to the accumulation of precise data, dissemination of accurate information, and the establishment of Anti-Aging Medicine as an evidence- and fact-based discipline which is approved and accepted by the medical community and society as a whole.
4. Research of Anti-Aging Medicine
・Insights yielded in this field are also helpful in scientifically elucidating phenomena occurring in biological processes throughout life, from birth to death.
・Anti-Aging Medicine deals with the biological process of aging.
It aims to prevent diseases, including lifestyle-related diseases; to control factors that promote the occurrence of disease, including stress, fatigue, and immunological deterioration and to promote and prolong a healthy life span.
・From the genetic and cellular level to the individual level of animals and humans, Anti-Aging Medicine covers diverse fields of medical science, including biochemistry, physiology, and clinical medicine, and takes a multidisciplinary approach involving chemistry, physics, agriculture, pharmacy and others.
・Research results are utilized in the practice of Anti-Aging Medicine, which is supported by replacement therapy based on nutrition and endocrinology, and lifestyle improvement, including physical exercise and rest.
Anti-Aging Medicine of Ophthalmology
Anti-Aging Medicine of Dental Medicine
Appearance for Skin and Beauty
Anti-Aging Medicine of Urology
Anti-Aging for Women’s Health
Anti- Aging Medicine of CVD
Anti- Aging Medicine of locomotorium
6. Progress and future of Anti-Aging Medicine
・How to activate GDF-11.
・Solve physical and mental problems that are factors preventing elderly people from participating in society.
・Reduce medical expenses